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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NEK2
All Species:
22.42
Human Site:
S300
Identified Species:
35.24
UniProt:
P51955
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P51955
NP_002488.1
445
51763
S300
P
E
K
S
Q
D
S
S
P
V
L
S
E
L
K
Chimpanzee
Pan troglodytes
XP_514178
522
59597
S377
P
E
K
S
Q
D
S
S
P
V
L
S
E
L
K
Rhesus Macaque
Macaca mulatta
XP_001108740
445
51674
S300
P
E
K
L
Q
D
S
S
P
V
L
S
E
L
K
Dog
Lupus familis
XP_537144
668
75595
S523
P
E
K
L
Q
D
S
S
P
V
L
G
E
L
K
Cat
Felis silvestris
Mouse
Mus musculus
O35942
443
51289
S300
P
S
K
L
P
D
S
S
P
V
L
S
E
L
K
Rat
Rattus norvegicus
XP_001055166
443
51340
S300
P
S
K
L
Q
D
S
S
P
V
L
S
E
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509538
499
57433
G354
P
E
R
L
Q
N
S
G
S
L
L
A
E
Q
K
Chicken
Gallus gallus
NP_001026221
444
51581
D299
P
E
R
V
Q
H
S
D
A
P
V
N
E
L
K
Frog
Xenopus laevis
NP_001079490
442
52004
D299
Q
E
R
L
S
T
P
D
P
V
P
S
E
L
R
Zebra Danio
Brachydanio rerio
Q90XC2
697
76523
S460
V
Q
V
S
C
G
A
S
H
V
L
A
V
T
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_572415
735
82962
Q393
E
E
R
A
E
E
R
Q
V
E
L
A
E
E
R
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_786794
453
51921
E287
A
D
A
P
K
E
A
E
V
D
L
L
K
K
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9CAU7
606
68016
L383
P
R
S
D
L
G
Q
L
P
V
S
S
Q
L
K
Baker's Yeast
Sacchar. cerevisiae
P22209
435
51185
L294
P
F
Q
A
K
N
Y
L
E
L
Q
T
K
I
K
Red Bread Mold
Neurospora crassa
P48479
858
94329
D321
N
K
R
I
R
E
L
D
S
K
L
S
A
L
E
Conservation
Percent
Protein Identity:
100
85
98.4
62.5
N.A.
87.6
89.4
N.A.
69.7
77
73.9
25.8
N.A.
30.2
N.A.
N.A.
54.3
Protein Similarity:
100
85
99.3
65.4
N.A.
94.1
95
N.A.
80.9
88.7
86.7
39
N.A.
44.3
N.A.
N.A.
72.1
P-Site Identity:
100
100
93.3
86.6
N.A.
80
86.6
N.A.
46.6
46.6
40
26.6
N.A.
20
N.A.
N.A.
6.6
P-Site Similarity:
100
100
93.3
86.6
N.A.
80
86.6
N.A.
73.3
66.6
53.3
46.6
N.A.
60
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
27.2
22.7
24.3
Protein Similarity:
N.A.
N.A.
N.A.
44.8
43.8
36.1
P-Site Identity:
N.A.
N.A.
N.A.
40
13.3
20
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
66.6
53.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
7
14
0
0
14
0
7
0
0
20
7
0
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
7
0
40
0
20
0
7
0
0
0
0
0
% D
% Glu:
7
54
0
0
7
20
0
7
7
7
0
0
67
7
14
% E
% Phe:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
14
0
7
0
0
0
7
0
0
0
% G
% His:
0
0
0
0
0
7
0
0
7
0
0
0
0
0
0
% H
% Ile:
0
0
0
7
0
0
0
0
0
0
0
0
0
7
0
% I
% Lys:
0
7
40
0
14
0
0
0
0
7
0
0
14
7
67
% K
% Leu:
0
0
0
40
7
0
7
14
0
14
74
7
0
67
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
0
0
14
0
0
0
0
0
7
0
0
7
% N
% Pro:
67
0
0
7
7
0
7
0
54
7
7
0
0
0
0
% P
% Gln:
7
7
7
0
47
0
7
7
0
0
7
0
7
7
0
% Q
% Arg:
0
7
34
0
7
0
7
0
0
0
0
0
0
0
14
% R
% Ser:
0
14
7
20
7
0
54
47
14
0
7
54
0
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
7
0
7
0
% T
% Val:
7
0
7
7
0
0
0
0
14
60
7
0
7
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _